*Practice limited to proceedings before the U.S. Patent and
Trademark Office
Professional Profile
Bar Admission
U.S. Patent and Trademark Office, 2012
Education
M.S. (1987)
University of Maryland (Nutritional Biochemistry)
B.S. (1984)
University of Maryland (Biochemistry)
Languages
English
Chinese (Mandarin and Shanghainese Dialects)
Publications
Yu, Betty R., Co-Author, “Enamino-oxindole HIV Protease
Inhibitors” 22 Bioorg. Med. Chem. Lett. 5078-5083 (2012)
Yu, Betty R., Co-Author, “Novel uncomplexed and complexed
structures of plasmepsin II, an aspartic protease from
Plasmodium falciparum,” 327 J. Mol. Biol. 173-181 (2003)
Yu, Betty R., Co-Author, “Drug resistance mutations can affect
dimer stability of HIV-1 protease at neutral pH,” 8 Protein
Science 1702-1707 (1999).
Yu, Betty R., Co-Author, “Kinetic characterization of RS-344,
an HIV-1 protease inhibitor designed with a 'resistant
repellent' core,” 4 Antiviral Therapy (1999).
Yu, Betty R., Co-Author, “A new series of potent, orally
bioavailable, non-peptidic cyclic sulfones as HIV-1 protease
inhibitors,” 39(18) J. Am. Chem. Soc. 3431-3434 (1996)
Yu, Betty R., Co-Author, “Kinetic characterization and
cross-resistance patterns of HIV-1 protease mutants selected
under drug pressure,” 34 Biochemistry 9282-9287 (1995)
Yu, Betty R., Co-Author, “Expression of growth-related genes
during tumor progression in v-raf transformed rat liver
epithelial cells,” 50 Cancer Research 7460-7467 (1990)
Yu, Betty R., Co-Author, “Purification and characterization of
UDP -GlcNAc:dolichol phosphate GlcNAc-1-phosphotransferase
from bovine mammary gland,” 263 J. Biol. Chem. 15964-15972
(1988)
Professional Experience
Scientific research experience: Sequoia Pharmaceutical, Inc.,
Tibotec Inc., and National Cancer Institute.
Patent technology transfer experience: Office of Technology
Transfer and Development, National Institute of Diabetes &
Digestive & Kidney Diseases (NIDDK), National Institutes of
Health (NIH).
Professional Membership
American Intellectual Property Law Association
Licensing Executives Society
Chinese Biopharmaceutical Association
Presentations
Yu, Betty R., Co-Author, “HIV PIs with Excellent resistance
Profile,” 2008 Gordon research Conference on Medicinal
Chemistry, New London, NH, August 2008.
Yu, Betty R., Co-Author, “Antiviral Activity of SPI-256
against WT and MDR Strains,” 15th International HIV Drug
Resistance Workshop, Sitges, Spain, June 2006.
Yu, Betty R., Co-Author, “Highly potent HIV protease
inhibitors with broad activity against MDR stains,” XIII
International HIV Drug Resistance Workshop, Canary islands,
Spain, June 2004.
Yu, Betty R., First Author, “Development of a relational
database for structure-based drug design,” RAMC 99 Conference,
San Diego, CA, August 1999.
Yu, Betty R., Co-Author, “Structures of plasmepsin II in
complex with non-peptidic inhibitors,” VIII International
Aspartic Proteinase Conference, September 1999.
Yu, Betty R., Co-Author, “The not-so-great escape: Drug
resistance studies with HIV protease,” 217th American Chemical
Society National Meeting, Anaheim, CA, March 1999.
Yu, Betty R., Co-Author, “Design and parallel synthesis of
human cathepsin D inhibitor libraries,” 39th Annual Buffalo
Medicinal Chemistry Symposium, May 1998.
Yu, Betty, R., Co-Author, “Structural studies of drug
resistance for HIV-1 protease mutants,” American
Crystallographic Association, Montreal, Canada, July 1995.